Simon is a Professor of Molecular Evolution with research interests in molecular clocks, evolutionary rates, phylogenetic methods, genomic evolution, and molecular ecology. Since co-founding the Molecular Ecology, Evolution, and Phylogenetics Lab in the School of Life and Environmental Sciences in 2011, he has supervised more than 20 Honours and PhD research students.
Simon did postdoctoral research with Lindell Bromham at the Australian National University and with Beth Shapiro and Peter Holland at the University of Oxford. He completed a DPhil degree in 2006 at the University of Oxford under the supervision of Andrew Rambaut, Alan Cooper, Alexei Drummond, and Richard Fortey. His MSc Research (2003) and BSc Honours (2002) were completed at the University of Sydney.