People in the Philippines have the most Denisovan DNA

Researchers have known from several lines of evidence that the ancient hominins known as the Denisovans interbred with modern humans in the distant past. Now researchers reporting in the journal Current Biology have discovered that the Philippine Negrito ethnic group known as the Ayta Magbukon have the highest level of Denisovan ancestry in the world. In fact, they carry considerably more Denisovan DNA than the Papuan Highlanders, who were previously known as the present-day population with the highest level of Denisovan ancestry.

“We made this observation despite the fact that Philippine Negritos were recently admixed with East Asian-related groups – who carry little Denisovan ancestry, and which consequently diluted their levels of Denisovan ancestry”, said Maximilian Larena of Uppsala University. “If we account for and masked away the East Asian-related ancestry in Philippine Negritos, their Denisovan ancestry can be up to 46 percent greater than that of Australians and Papuans.”

In the new study, Larena and colleagues, including Simon Ho from the University of Sydney, aimed to establish the demographic history of the Philippines. The work was carried out through a partnership between Uppsala University of Sweden and the National Commission for Culture and the Arts of the Philippines, aided by collaboration with indigenous cultural communities, local universities, local government units, non-governmental organisations, and regional offices of the National Commission for Indigenous Peoples.

The team analysed about 2.3 million genotypes from 118 ethnic groups of the Philippines, including diverse self-identified Negrito populations. The sample also included high-coverage genomes of AustraloPapuans and Ayta Magbukon Negritos.

The study shows that Ayta Magbukon possess the highest level of Denisovan ancestry in the world, consistent with an independent admixture event into Negritos from Denisovans. Together with the recent discovery of a small-bodied hominin, called Homo luzonensis, the data suggest that there were multiple archaic species that inhabited the Philippines prior to the arrival of modern humans, and that these archaic groups may have been genetically related.

The findings unveil a complex intertwined history of modern and archaic humans in the Asia-Pacific region, where distinct Islander Denisovan populations differentially admixed with incoming Australasians across multiple locations and at various points in time.

“By sequencing more genomes in the future, we will have better resolution in addressing multiple questions, including how the inherited archaic tracts influenced our biology and how it contributed to our adaptation as a species”, Larena said.

This work was supported by the Swedish Research Council and the Knut and Alice Wallenberg Foundation.

Reference

Larena M, McKenna J, Sanchez-Quinto F, Bernhardsson C, Ebeo C, Reyes R, Casel O, Huang J-Y, Hagada KP, Gullay D, Reyes J, Allian FP, Mori V, Azarcon LS, Manera A, Terando C, Jamero L, Sireg G, Manginsay-Tremedal R, Labos MS, Vilar RD, Latiph A, Saway RL, Marte E, Magbanua P, Morales A, Java I, Reveche R, Barrios B, Burton E, Salon JC, Kels MJT, Albano A, Cruz-Angeles RB, Molanida E, Granehäil L, Vicente M, Edlund H, Loo J-H, Trejaut J, Ho SYW, Reid L, Lambeck K, Malmström H, Schlebusch C, Endicott P, Jackobsson M. 2021. Philippine Ayta possess the highest level of Denisovan ancestry in the world. Current Biology, in press.